MK-677 A10, or otherwise known as Ibutamoren, has widely been discussed in online forums. The main subject for it is in its anabolic muscle-building properties. The over-the-counter drug is utilized by a lot of people who are in need of increasing their growth hormone (GH) levels. MK-677 naturally secretes GH while increase IGF-1 (insulin-like growth factor).
It increases GH levels by copying the mechanisms of hormone ghrelin. It attaches itself to one of the ghrelin receptors (GHSR) within the brain. The GSHR that’s been activated then stimulates the release of GH from the brain.
One of the biggest things with MK-677 is how it’s capable of increasing GH levels with minimal to zero increase in other hormones like that of cortisol. Cortisol is responsible for suppressing the immune system, minimizes the healing of wounds, and hinders memory and learning ability. It’s never a good idea to have this particular hormone activated.
MK-677 has a plenty of advantages when taken at proper doses. For instance, it:
1.Aids in building muscles
The drug is constantly being utilized as an anabolic substance. It increases lean body mass, hence development of larger muscles. It can only be taken orally once daily. It’s one of the biggest benefits compared to that other GH stimulators.
2.Minimizes wasting of muscle. In a clinical study involving
volunteers deprived of food, MK-677 completely reversed protein loss. Therefore, muscle wasting is prevented. In patients with a hip fracture, the drug was a big help in enhancing gait and in muscle strengthening. This led to lesser chances of falls.
3.Promotes an increase in bone density
GH leads to an increase in bone turnover as well as bone density. However, due a large turnover increase as a result of being treated with GH, bone density may slight decrease in the early stage. But the process eventually leads to increased bone density. Careful observation is required since it takes under a year or so for increased bone density.
4.Promotes better sleep
One clinical study showed that in both young and older patients, the drug enhanced the quality of REM (Rapid Eye Movement) and duration of sleep. Aside from that, multiple online reports showed improvement in sleep.
5.Fights aging and improves longevity
Secretion of GH and muscle mass typically decline starting at mid-puberty and for the remainder of a person’s life. In a recent study in older people, intake of MK-677 significantly increased IGF-1 and GH levels in par of levels seen in young adults without any serious side effects. It’s been said that IGF-1 is beneficial for longevity.
6.Effectively treats Growth Hormone Deficiency (GHD)
MK-677 triggers IGF-1 and IGFPB-3 levels in children suffering from GH deficiency. What’s more, such effects are stored without any changes in glucose, prolactin, T4, T3, cortisol, or insulin. In males who are significantly deprived of GH, the drug enhanced the IGF-1 and GH levels without any alterations with cortisol and TH levels.
7.Aids in healing and regeneration of tissues
GH enhances the regeneration of tissue and healing of injuries so it’s expected that MK-677 may have had a hand in such. Numerous anecdotal accounts of the drug and its benefit have been reported by a number of users worldwide.
Main Side Effects Frequent side effects attributed to MK-677 include increased appetite, mild edema in the lower extremity, and muscle pain. Some studies have reported a significant increase in fasting blood glucose. Some experienced a decreased in insulin sensitivity.
These side effects are strikingly similar to individuals whose GH levels are elevated and those with resistance to insulin and joint pain.
While a majority of studies have showcased reports of minimal to zero side effects, one study had to be ended due adverse reactions. In one particular incident involving elderly patients suffering from a fracture hip, MK-677 increased blood pressure, HbA1x, and blood glucose. Some even suffered from congestive heart failure. It’s important to take note that these patients with heart failure were those who were 80 years of age and have had a previous medical history of heart failure(s).
When it comes to dietary regimen, one needs to watch their carbohydrate intake. Insulin and blood sugar levels should be regularly monitored. It’s always a good idea to avoid the drug at all costs if one has cancer. Intake of MK-677 could increase the proliferation of cancer cells.
It’s never recommended to take MK-677 if one is Th1 dominant as GH has a immune-stimulating functionality.