Andarine (a.k.a. S-4, S-4003, GTx-007, Acetamidoxolutamide, Androxolutamide,) is a selective androgen receptor modulator (SARM) created for treating osteoporosis and benign prostatic hyperplasia. It’s one of the potent forms of SARM minus the toxic effects that you get from Winstrol such as liver toxicity, baldness, and depression.
The effect of Andarine was initially observed on lab mice. The research showed that Andarine increased muscle mass and bone density with completely selective tissue growth. Because of its efficacy and potency, Andarine S4 uses are in demand for those who wish to build lean muscle mass.
First, we’ll discuss what Andarine targets (which is the androgen receptor) so that you’ll fully understand the Andarine’s mechanism of action.
The androgen receptor is a nuclear receptor serving as a transcription factor (more like an on and off switch) for gene expression. It plays a vital function in both development and maintenance of your body systems, but today we’ll concentrate on its action on the musculoskeletal system.
Three types of compounds bind to an androgen receptor (AR):
Because the Andarine is a form of SARM, it triggers the AR to react to testosterone by producing genes necessary for musculoskeletal growth. This means that S-4 can trigger muscular development much like steroids do but without the undesirable side effects. Production of muscle mass occurs by boosting the effect of testosterone by lowering your body’s sensitivity to natural testosterone.
Athletes and bodybuilders are particular to Anardine because of its capabilities for muscle building and fat reduction. Here’s where you can Andarine based on your goals for body sculpting.
Although Anardine is created to prevent muscle wasting, using S-4 on its own does not provide impressive results. If used on its own, Anadrine utilizes excess calories by forming 8-10 lbs of lean muscle. However, it’s impressive if paired with a bulking SARM like Ostarine or Ligandrol.
Another reason Anadrine’s popularity is its capability to increase strength comparable to steroids. This is highly beneficial if you’re on your cutting cycle wherein there’s a loss in strength gains. A dose of 50mg of Andarine + 10mg of Ligandrol can provide strength gains that are noticeable in 2-3 weeks.
Cutting is a stressful phase in bodybuilding. You have to eat less and increase your cardio to gain lean muscle and shed body fat. Andarine stacked with Cardarine helps provide excellent results in 12 weeks. By binding with androgen receptors, Andarine commands your body to shed fat and increase muscle density.
Andarine helps in increasing bone density and strength, which gives bodybuilders lift weights better. Patients with osteoporosis may benefit from S-4 intake in two ways: aside from improving bone density, there is a development in muscle strength, reducing the risk of falls and fractures.
Caution is when taking advantage of Andarine S4 uses. Start with low doses and do not exceed the recommended daily intake. Some report visual disturbances such as yellowish sight and eye discomfort when taking high doses of Andarine.
What is your goal for using Andarine? How did it help you achieve your goal in body sculpting? Please don’t hesitate to share your experience in the comment section!