MK-677 which is also known as Ibutamoren or Nutrobal is a Selective Androgen Receptor Modulator (SARM). Most newer SARMs are non-steroidal but have similar anabolic properties to steroids. MK-677 and most SARMs differ from steroids by how they bind to androgen receptors (ARs). Most of the popular steroids are full agonists of the ARs however, non-steroidal SARMs selectively bind to specific ARs due to their unique chemical composition.
The majority of SARMs developed target primarily lean muscle mass and bone tissues. It has a high affinity for ARs in lean muscle and bone tissue and a lower affinity in other tissues.
Another interesting effect of MK-677 is its effect on growth hormone and IGF-1 release. It increases GH levels my mimiking the hormone, ghrelin and attaches to ghrelin receptors in the brain. Activated ghrelin receptors in the brain then release GH. GH has some minor anabolic properties and can help with muscle repair, decrease muscle catabolization and increase bone density. Increased GH levels have anabolic properties and can also help with muscle, joint and tendon recovery and also have other positive benefits such as: increased metabolic rate, improved mood, memory and cognition.
Nutrobal also increases IGF-1 (Insulin-Like-Growth-Factor-1) which has positive benefits similar to GH. MK-677 does not seem to affect other important hormones and does not seem to increase cortisol (stress hormone).
Science behind MK 677 (Our Review)
MK-677 is non-peptidic, orally active and has dual anabolic properties. Like other SARMs, Nutrobal targets androgen receptors with a high selectivity for ones in muscle and bone tissues. It differs from anabolic steroids as it is not technically a true agonist for the androgen receptors although, at the ARs MK-677 binds too it displays full agonistic properties. The reason this substance cannot be considered a full agonist is due to the unique ways it targets specific androgenic receptors.
How MK-677 and other SARMs selectively target specific androgen receptors is unclear. One popular hypothesis suggests that each SARM has a unique molecular arrangement and when attached to the androgen receptor it temporarily changes the molecular arrangement of the host receptor. This molecular change then induces subsequent signaling through genetic or non-genetic processes.
1- Athletic uses: It causes a rise in IGF-1 and growth hormones directly. It helps combat diet induced nitrogen waste. This means you gain muscle mass and lose body fat in a more organic manner. While you may not encounter great strength with Nutrobal, athletes benefit from it in other ways such as- bone strengthening, faster injury healing etc.
Moreover, it aids in the overall health quotient by helping you get better sleep, physical endurance, and better mood.
2- Medical uses: To treat geriatric diseases such as frailty, it is becoming a promising health supplement. Additionally due to its growth hormone secreting properties, it is being developed as a growth drug for children.
MK 677 and calorie restriction
Growth hormone treatment has been reported to preserve muscle mass. When on a high-calorie restriction, it combats loss of muscles andhelps preserve muscle mass respectively.
Albeit, there has been some research on the dosage, a recommended 25mg/day is prescribed as an effective (clinical) dose. It is also possible that lower doses are also effective, but not as much as the optimal ones.
At this dose, MK-677 is reported to work efficiently and is almost well tolerated by our body.
Since it does not interfere negatively or suppress the natural ability of the body to produce GH, it is not necessary to cycle it off.
The average time for using it usually around 8 weeks. Unlike a SARM, it doesn’t shut down your natural production of testosterone. It doesn’t have any impact on sex hormones, but improved health benefits contribute to a better sexual performance.
In one study, participants consumed it for 12 months, with 25 mg/day prescribed dosage with no reported adverse consequences.
Our body releases more of GH during our sleep. For this very reason, many fitness mongers consume it while going to bed. But despite the fact, timing is not an issue for Ibutamoren to work for the body.
A noteworthy point to remember is- it has a half-life of 24-25 hours. So, it doesn’t matter much what time it is consumed. The constant working of the supplement for a full 24 hours makes it easy for its intake irrespective of the time.
Nutrobal’s unique properties and lesser side-effects make it a suitable drug to stack with other compounds.
The list of common health supplements that are stacked with Nutrobal or Ibutamoren is Ostarine, Andarine, Cardarine.
Out of these 3 compounds, Cardarine is the most suitable stackable compound with Nutrobal. Because it promotes fat loss and has protein sparing abilities, it forms a great companion with MK-677.
Caution:It is advisable not to exceed 20 mg of Cardarine while stacking.
Being an HGH analogue and consumed orally, MK-677 has been credited with many positive results and benefits. Thus, it helps in
- Shedding weight
- Repairing nerve damage
- Boost the immunity to heal cuts and wounds quickly
- Shoots up the level of growth hormones
- Protecting muscle mass
- Boosting lean muscle gain
- Better cognitive functioning
- Improve sleep quality and REM sleep duration (considered a nootropic)
- Improving complexion
Nutrobal is not without some downsides.
With its anabolic properties, it can cause an increase in appetite and you may feel hungry all the time. Plus, your body’s water retention capability may also rise. Numb hands (for some period of time), muscle pain and lethargy account for the next problems faced with using MK 677. It has also shown to cause edema.
No doubt, it has been called the fountain of youth, and works wonders for your body, but due to some health issues surrounding it (like production of cancer cells with healthy cells too), it is sold as a dietary supplement and not as a bodybuilding pill or the sort.