MK677 is a supplement has more discussions found in online forums compared to the clinical research being done. So far, research does showcase support for the benefits it’s offering including the ability to increase IGF-1 (Insulin Growth Factor-1) and GH (Growth Hormone) levels.
The supplement is widely talked about in blog sites and online forums for its muscle-building abilities. It’s sold over-the-counter in drug stores and utilized by those who want to increase their GH levels. However, only a few clinical studies were made on the compound.
MK677 is a drug known for promoting the secretion of GH levels and increasing IGF-1. It’s able to do this by mimicking the action of the hormone ghrelin as well as attaching to any of the GHSR (Ghrelin Receptors) within the brain. The GHSR that has been activated triggers the release of GH from within the brain.
GHSR is seen in regions of the brain that controls mood, pleasures, appetite, memory, cognition, and other biological rhythms. So, it’s expected for the drug to have influence in these functions. So far, clinical studies that have been carried out only proves the effect that the drug has on appetite.
One biggest upside with the drug is that increases GH levels with little or no increase in other hormone levels like that of Cortisol. Cortisol is responsible for suppressing the immune system, decreasing the healing of wounds, and impairing cognition. Hence, it’s never a good idea for such hormone to be elevated.
MK677 offers a number of benefits to the human body. These include:
The drug has been used regularly as an anabolic product to increase one’s lean body mass or building bigger muscles. It can be taken orally once per day. This is the biggest benefit that this supplement has over other GH stimulators.
As indicated, MK677 is capable of increasing GH and IGF-1 levels. In turn, these hormones help increase muscle strength, muscle mass, and minimizing unwanted body fat.
In one study involving several volunteers deprived of food, the supplement was more than capable of reversing diet-induced protein loss, which could lead to muscle wasting.
In another study involving more than one hundred elderly patients suffering from a hip fracture, MK677 helped enhanced their muscle strength and speed in gait while significantly reducing the number of falls.
GH is responsible for increasing bone density and bone turnover. But due to the increased turnover seen in volunteers that have been treated with GH, it was observed that bone density can decrease initially before substantially increasing later. The time it takes for bone density to increase will take around a year or more.
In a study involving obese male volunteers, the substance was able to increase bone turnover. In another study done involving adults 65 years or over in age, MK677 was able to increase bone building properties as indicated by osteocalcin, a biological marker of bone turnover seen in numerous studies.
Another study that involved nearly 300 post-menopausal women showed how the drug was able to increase bone mineral density, which aid in increasing bone strength and curbing osteoporosis.
One study involving young adults and elderly subjects showed how the supplement has improved their quality of sleep, sleep duration, and REM (Rapid Eye Movement). Other than the scientific studies made, numerous users from different online forums have reported a dramatic improvement in their quality of sleep.
It’s expected that one can’t perform their best working out when they don’t get a good night’s sleep. That’s why it’s important to have a restful sleep to ensure one is at their “peak” when they work out or take part in competitive sports.
Secretion of the GH and quality of muscle mass tend to decline once one hits their mid-puberty. In a study involving elderly males and females, taking MK677 regularly has helped increased both their IGF-1 and GH levels without any adverse effects. It’s been shown that IGF-1 is beneficial in promoting longevity.
In one study involving obese males, the supplement helped rejuvenate their GH profile.
Some individuals have made use of MK677 as a nootropic since it directly acts on the Ghrelin receptor, which has nootropic effects. However, there has yet been any study done that would attribute the drug’s effectiveness in improving an individual’s cognition.
There are two indirect processes in which the supplement can aid in improving brain function. These are:
-The ability of the drug to increase IGF-1 levels, which is known for improving cognition and memory.
-The ability to further increase REM, sleep quality, and sleep duration.
One area in question was the association of IGF-1 levels and Alzheimer’s disease, and whether MK677 could be of tremendous help. But based on one study, the product was incapable the progression of Alzheimer’s in humans.
MK677 is shown to increase GH, IGFBP-3, and IGF-1 levels in children suffering from GH deficiency. What’s more, such effects are achieved without intervening prolactin, T3, T4, Cortisol, or insulin concentrations.
In males with severe GH deficiency, the drug has been shown to increase both IGF-1 and GH levels without major alterations in thyroid, PRL, and Cortisol levels. But there was noticeable increase in both glucose and insulin levels.
GH promotes an increase in tissue regeneration and healing of wounds. Since the drug is closely associated in increasing GH levels, it’s fair to conclude that MK677 can be of big help. There have been numerous subjective reports of the supplement being a helpful although scientific studies are severely limited.
At this point, reports of the drug capable treating hangovers are anecdotal. But there have been frequent instances of individuals using MK677 to treat hangovers.
One of the lesser known side effects of the supplement include:
-Increase in appetite.
-Mild edema in the lower extremity.
-Mild muscle pain.
Some studies have reported a decrease in insulin sensitivity and an increase in fasting blood glucose. Such effects are similar to those who have increased GH levels, insulin resistance, and joint pain.
While a majority of studies have reported little or no side effects, one recent study had to be terminated due to major adverse events.
In the elderly who have a hip fracture, the drug may lead to an increase in blood pressure, HbA1c, and blood glucose. In certain cases, some suffered congestive heart failure. But patients with such condition were over 80 years of age and has a history of cardiovascular problems.
It’s imperative to check one’s carbohydrate intake, insulin, and blood sugar levels while taking the drug.
As an anabolic compound, MK677 shouldn’t be taken if one is dealing with cancer. Both IGF-1 and GH could further promote cancer growth. It’s also recommended to not take the drug if one is Th1 dominant as the GH naturally stimulates the immune system.